I-2 DNA Replication

PCNA and DNA replication ( I )

Replication of the entire genome during S-phase is one of the most important cell cycle events and requires the coordinated activity of a multitude of different enzymes. Proliferating cell nuclear antigen (PCNA) interacts directly and indirectly with most of these proteins and thereby plays a leading part in the coordination of the replication process. PCNA is the processivity factor for the re...

Replication in Drosophila chromosomes. I. Replication of intranucleolar DNA in polytene cells of D. nasuta.

The organization and replication of intranucleolar DNA in polytene cells of Drosophila nasuta have been examined. Normal Giemsa and fluorescent (Hoechst 33258 and quinacrine mustard) staining reveal that in D. nasuta polytene cells, the intranucleolar DNA is organized into condensed and disperse forms and very often shows connexion to the alpha heterochromatin of the chromocentre. Results of [3...

DNA replication.

2-absorbing $I$-prime and 2-absorbing $I$-second submodules

Let $R$ be a commutative ring and let $I$ be an ideal of $R$. In this paper, we will introduce the notions of 2-absorbing $I$-prime and 2-absorbing $I$-second submodules of an $R$-module $M$ as a generalization of 2-absorbing and strongly 2-absorbing second submodules of $M$ and explore some basic properties of these classes of modules.

Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1-DNA cleavage complexes (Top1cc's) and inducing replication-associated DNA double-strand breaks (DSBs). In this paper, we propose a new mechan...